Faculty / Supporting Staff, Department of Pharmaceutical Sciences - Dr. Sahar Alghamdi

 

 

Dr. Sahar S. Alghamdi, PhD

Assistant Professor of Medicinal Chemistry Track, COP-Female Branch

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Education:

  • Doctor of Philosophy in Medicinal Chemistry, The University of Tennessee Health Science Center, Tennessee,USA, 2020
  • Master of Science in Medicinal Chemistry, The University of Florida, Florida, USA, 2016
  • Bachelor of Science in Pharmacy, King Saud University, Riyadh, KSA, 2012

Research Interest:

  • Pharmacological, and biological evaluation of synthetic cannabinoid ligands using multiple functional assays (G-protein and β-arrestins signaling) and radioligand binding affinity studies at human CB1 and CB2 receptors.
  • Investigation of the anti-inflammatory properties of multiple cannabinoids in neurodegenerative diseases in-vitro models by evaluating the M1 and M2 microglia phenotypes, pro and anti-inflammatory cytokines production, and multiple signaling pathway upon cannabinoid drug treatment in murine (C8B4) and human (immortalized SV40 cells) microglial cells.
  • Assessment of protein-ligand molecular interactions (at CB1 and CB2 receptors) that produced specific (experimental) pharmacological profile using computational techniques (GPCR homology models, protein-ligands molecular dynamic simulations MD, flexible and induced fit molecular docking, QSAR studies) using Schrödinger software (prime, glide, desmond, Pharmacophore modeling, 3D-QSAR).

 

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